Single Cell Atlas of Human Ocular Surface scRNA-seq: Cornea, Limbus, Sclera

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Cell Metadata

Lymphatic Endothelium

Ontology Term: endothelial cell of lymphatic vesselCL:0002138
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: LEC, lymphatic endothelial cell
Category Class of which the cell type is a subclass.: endothelial cell of vascular treeCL:0002139
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CCL21, TFPI, PPFIBP1, B2M, MMRN1, IGFBP7, CLDN5, GNG11, HLA-E, ARL4A
Canonical Marker Genes: CCL21, LYVE1
Rationale: 96.9% LEnC from Shi dataset; 100% lymphatic vessels from Lako adult dataset; 44.8% blood vessels from Lako fetal dataset; majorclass annotated by PECAM1, celltype annotated by CCL21

Set of Labels Description: This atlas is an integrated collection of over 815k cells, derived from single-cell RNA-seq data of human ocular surface, including cornea, limbus, and anterior sclera. These cells have been categorized into 10 major cell classes and 31 types. This is the initial cell type label for the atlas annotation. These labels will be examined, refined, and updated during the annotation jamboree.
Annotation Method: manual

Ontology Term: endothelial cell of lymphatic vesselCL:0002138
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: LEC, lymphatic endothelial cell
Category Class of which the cell type is a subclass.: endothelial cell of vascular treeCL:0002139
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CCL21, TFPI, PPFIBP1, B2M, MMRN1, IGFBP7, CLDN5, GNG11, HLA-E, ARL4A
Canonical Marker Genes: CCL21, LYVE1
Rationale: 96.9% LEnC from Shi dataset; 100% lymphatic vessels from Lako adult dataset; 44.8% blood vessels from Lako fetal dataset; majorclass annotated by PECAM1, celltype annotated by CCL21

Set of Labels Description: This atlas is an integrated collection of over 815k cells, derived from single-cell RNA-seq data of human ocular surface, including cornea, limbus, and anterior sclera. These cells have been categorized into 10 major cell classes and 31 types. This is the initial cell type label for the atlas annotation. These labels will be examined, refined, and updated during the annotation jamboree.
Annotation Method: manual