Single Cell Atlas of Human Ocular Surface scRNA-seq: Cornea, Limbus, Sclera

Main

Cell Metadata

Macrophages

Ontology Term: macrophageCL:0000235
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: histiocyte
Category Class of which the cell type is a subclass.: myeloid leukocyteCL:0000766
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: SRGN, CD83, HLA-DRA, KYNU, CD74, CXCL8, CCL3, DOCK4, TYROBP, HLA-DRB1
Canonical Marker Genes: C1QA, C1QB
Rationale: 46.8% ImC from Shi dataset;61.1% immune cells from Lako adult dataset;28% immune cells from Lako fetal dataset; majorclass annotated by PTPRD, celltype annotated by C1QA, C1QB

Set of Labels Description: This atlas is an integrated collection of over 815k cells, derived from single-cell RNA-seq data of human ocular surface, including cornea, limbus, and anterior sclera. These cells have been categorized into 10 major cell classes and 31 types. This is the initial cell type label for the atlas annotation. These labels will be examined, refined, and updated during the annotation jamboree.
Annotation Method: manual

Ontology Term: macrophageCL:0000235
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: histiocyte
Category Class of which the cell type is a subclass.: myeloid leukocyteCL:0000766
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: SRGN, CD83, HLA-DRA, KYNU, CD74, CXCL8, CCL3, DOCK4, TYROBP, HLA-DRB1
Canonical Marker Genes: C1QA, C1QB
Rationale: 46.8% ImC from Shi dataset;61.1% immune cells from Lako adult dataset;28% immune cells from Lako fetal dataset; majorclass annotated by PTPRD, celltype annotated by C1QA, C1QB

Set of Labels Description: This atlas is an integrated collection of over 815k cells, derived from single-cell RNA-seq data of human ocular surface, including cornea, limbus, and anterior sclera. These cells have been categorized into 10 major cell classes and 31 types. This is the initial cell type label for the atlas annotation. These labels will be examined, refined, and updated during the annotation jamboree.
Annotation Method: manual