Single cell atlas of the human trabecular meshwork and ciliary body - scRNA-seq

JCT

Ontology Term

fibroblastCL:0000057

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

unknown

Category

Class of which the cell type is a subclass.

connective tissue cellCL:0002320

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

—

Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

CHI3L1, ANGPTL7

Canonical Marker Genes

CHI3L1

Rationale

This JCT sub-class is annotated by the marker CHI3L1.

Inherited from author_cell_type

Set of Labels Description

This cell annotation set focuses on the trabecular meshwork (TM) and ciliary body (CB), key tissues regulating aqueous humor dynamics and intraocular pressure in the human eye. Using single-cell RNA-seq, we analyzed over 332K cells from 36 healthy donors, identifying 9 major cell classes and 19 sub-classes. As part of the Human Cell Atlas initiative, this dataset integrates transcriptomic and chromatin accessibility data and is publicly accessible via CELLxGENE and the UCSC Cell Browser, offering a valuable resource for understanding ocular physiology and disease mechanisms.

Annotation Method

manual