snRNA-seq of human of the human retinal pigment epithelium and the choroid

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Cell Metadata

Fibroblasts_SMOC2

Ontology Term: fibroblastCL:0000057
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: fibroblastCL:0000499
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PDGFRA, SMOC2
Canonical Marker Genes: PDGFRA
Rationale: This Fibroblasts_SMOC2 sub-class is annotated by its cell contribution from non-fetal donors and expression of markers PDGFRA and SMOC2.

Set of Labels Description: This cell annotation dataset focuses on the human retinal pigment epithelium (RPE) and choroid, which are essential for the survival and proper function of the neural retina in the human eye. Using single-nucleus RNA sequencing (snRNA-seq), we analyzed over 740K nuclei from 54 donors. Additionally, we incorporated snRNA-seq data from 136,555 nuclei from developmental RPE/choroid tissues spanning post-conception weeks (PCW) 10-23. This comprehensive dataset enabled the identification of 17 major cell classes and 36 sub-classes. As part of the Human Cell Atlas initiative, this resource lays a robust foundation for advancing research into the biology of the RPE and choroid and the diseases associated with these tissues.
Annotation Method: manual