snRNA-seq of human of the human retinal pigment epithelium and the choroid

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Cell Metadata

Smooth_muscle_cells_DGKI

Ontology Term: blood vessel smooth muscle cellCL:0019018
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: smooth muscle cell of blood vessel
Category Class of which the cell type is a subclass.: mural cellCL:0000359
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: ACTA2, MYH11, DGKI
Canonical Marker Genes: ACTA2, MYH11
Rationale: This smooth muscle cell DGKI sub-class is annotated by the markers ACTA2, MYH11, DGKI

Set of Labels Description: This cell annotation dataset focuses on the human retinal pigment epithelium (RPE) and choroid, which are essential for the survival and proper function of the neural retina in the human eye. Using single-nucleus RNA sequencing (snRNA-seq), we analyzed over 740K nuclei from 54 donors. Additionally, we incorporated snRNA-seq data from 136,555 nuclei from developmental RPE/choroid tissues spanning post-conception weeks (PCW) 10-23. This comprehensive dataset enabled the identification of 17 major cell classes and 36 sub-classes. As part of the Human Cell Atlas initiative, this resource lays a robust foundation for advancing research into the biology of the RPE and choroid and the diseases associated with these tissues.
Annotation Method: manual

Ontology Term: blood vessel smooth muscle cellCL:0019018
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: smooth muscle cell of blood vessel
Category Class of which the cell type is a subclass.: mural cellCL:0000359
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: ACTA2, MYH11, DGKI
Canonical Marker Genes: ACTA2, MYH11
Rationale: This smooth muscle cell DGKI sub-class is annotated by the markers ACTA2, MYH11, DGKI

Set of Labels Description: This cell annotation dataset focuses on the human retinal pigment epithelium (RPE) and choroid, which are essential for the survival and proper function of the neural retina in the human eye. Using single-nucleus RNA sequencing (snRNA-seq), we analyzed over 740K nuclei from 54 donors. Additionally, we incorporated snRNA-seq data from 136,555 nuclei from developmental RPE/choroid tissues spanning post-conception weeks (PCW) 10-23. This comprehensive dataset enabled the identification of 17 major cell classes and 36 sub-classes. As part of the Human Cell Atlas initiative, this resource lays a robust foundation for advancing research into the biology of the RPE and choroid and the diseases associated with these tissues.
Annotation Method: manual