Macrophages

Ontology Term

macrophageCL:0000235

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

histiocyte

Category

Class of which the cell type is a subclass.

mononuclear phagocyteCL:0000113

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

C1QB, F13A1, MRC1,

Canonical Marker Genes

C1QB, F13A1

Rationale

This macrophage MRC1+ sub-class is annotated by the markers C1QB, F13A1, MRC1

Inherited from author_cell_type

Set of Labels Description

This cell annotation dataset focuses on the human retinal pigment epithelium (RPE) and choroid, which are essential for the survival and proper function of the neural retina in the human eye. Using single-nucleus RNA sequencing (snRNA-seq), we analyzed over 740K nuclei from 54 donors. Additionally, we incorporated snRNA-seq data from 136,555 nuclei from developmental RPE/choroid tissues spanning post-conception weeks (PCW) 10-23. This comprehensive dataset enabled the identification of 17 major cell classes and 36 sub-classes. As part of the Human Cell Atlas initiative, this resource lays a robust foundation for advancing research into the biology of the RPE and choroid and the diseases associated with these tissues.

Annotation Method

manual