Skin fibroblast scRNA-seq atlas in health
F2: Universal
- Full Name
- Universal fibroblast
- Closest Ontology Term
- fibroblastCL:0000057
- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- Steady-state like fibroblast, Reticular fibroblast
- CategoryClass of which the cell type is a subclass.
- stromal cellCL:0000499
- Ontology AssessmentDisagreements with any aspect of the Cell Ontology.
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- Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.
- CD34, PI16, MFAP5, DPP4, PCOLCE2, LGR5, SLPI, CD70, CTHRC1
- Rationale
- We named this population based in highest expression of CD34, PI16, and MFAP5, which are reported as UniversalPi16+ fibroblast markers in Buechler et al. This population also had the highest expression of LGR5, in agreement with a potential stem state reported by Buechler. Universal fibroblasts have been reported in the stroma in skin (see McCartney et al. 2024 (in DOI links)). Our cross-tissue analysis also supported these fibroblasts as Universal. However, we note that F2/3: Perivascular fibroblasts also have universal features.
Inherited from cell_type
- Set of Labels Description
- Aim to harmonise skin fibroblast labels across studies in both health and disease. This specific dataset includes only healthy/non-lesional cells.
- Annotation Method
- manual