Skin fibroblast scRNA-seq atlas in health

Main

Cell Metadata

F1: Superficial

Full Name: Superficial fibroblast
Closest Ontology Term: skin fibroblastCL:0002620
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: Papillary fibroblast
Category Class of which the cell type is a subclass.: fibroblastCL:0000057
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: APCDD1, COL18A1, COL23A1, COL13A1, COMP, NKD2, RSPO1, AXIN2
Canonical Marker Genes: APCDD1, COL18A1, COL23A1
Rationale: LOCATION: Adjacent to epidermis. GENE EXPRESSION: Superficial dermal collagens (COL18, COL23) and WNT inhibitors (WIF1, RSPO1). SKIN-SPECIFIC: Papillary fibroblasts. CROSS-TISSUE INSIGHTS: Variable across tissues, which may reflect a role in imprinting epithelial identity. Highest similarity to nasal mucosa epithelia, which may reflect increased similarity of nasal mucosa epithelia to skin relative to other tissues.

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease. This specific dataset includes only healthy/non-lesional cells.
Annotation Method: manual

Full Name: Superficial fibroblast
Closest Ontology Term: skin fibroblastCL:0002620
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: Papillary fibroblast
Category Class of which the cell type is a subclass.: fibroblastCL:0000057
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: APCDD1, COL18A1, COL23A1, COL13A1, COMP, NKD2, RSPO1, AXIN2
Canonical Marker Genes: APCDD1, COL18A1, COL23A1
Rationale: LOCATION: Adjacent to epidermis. GENE EXPRESSION: Superficial dermal collagens (COL18, COL23) and WNT inhibitors (WIF1, RSPO1). SKIN-SPECIFIC: Papillary fibroblasts. CROSS-TISSUE INSIGHTS: Variable across tissues, which may reflect a role in imprinting epithelial identity. Highest similarity to nasal mucosa epithelia, which may reflect increased similarity of nasal mucosa epithelia to skin relative to other tissues.

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease. This specific dataset includes only healthy/non-lesional cells.
Annotation Method: manual