Skin fibroblast scRNA-seq atlas in health

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Cell Metadata

F3: FRC-like

Full Name: CCL19+ Fibroblast reticular-like cell
Closest Ontology Term: fibroblastic reticular cellCL:0009101
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: fibroblastCL:0000057
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CCL19, CD74, CH25H, TNFSF13B, IL33, IRF8, IL15, VCAM1, HLA-DRB1, HLA-DRA
Canonical Marker Genes: CCL19, CD74, CH25H, VCAM1
Rationale: LOCATION: Superficial perivascular region in immune niche (lesser extent immune niche adjacent to hair follicles). GENE EXPRESSION: Similar gene expression to FRCs (specialised fibroblast populations in lymphoid tissue), particularly to T zone reticular cells (CCL19, CH25H, IL33, TNFSF13B, IL33). CROSS-TISSUE INSIGHTS Observed in different tissues. Similar to intestinal T zone reticular cells that are enriched in IBD.

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease. This specific dataset includes only healthy/non-lesional cells.
Annotation Method: manual

Full Name: CCL19+ Fibroblast reticular-like cell
Closest Ontology Term: fibroblastic reticular cellCL:0009101
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: fibroblastCL:0000057
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CCL19, CD74, CH25H, TNFSF13B, IL33, IRF8, IL15, VCAM1, HLA-DRB1, HLA-DRA
Canonical Marker Genes: CCL19, CD74, CH25H, VCAM1
Rationale: LOCATION: Superficial perivascular region in immune niche (lesser extent immune niche adjacent to hair follicles). GENE EXPRESSION: Similar gene expression to FRCs (specialised fibroblast populations in lymphoid tissue), particularly to T zone reticular cells (CCL19, CH25H, IL33, TNFSF13B, IL33). CROSS-TISSUE INSIGHTS Observed in different tissues. Similar to intestinal T zone reticular cells that are enriched in IBD.

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease. This specific dataset includes only healthy/non-lesional cells.
Annotation Method: manual