Skin fibroblast scRNA-seq atlas in health

F5: NGFR+

Full Name

Schwann-like fibroblast (NGFR+)

Closest Ontology Term

skin fibroblastCL:0002620

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

Nerve-associated fibroblast

Category

Class of which the cell type is a subclass.

fibroblastCL:0000057

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

NGFR, ITGA6, SCN7A, CDH19, CLDN1, SFRP4, TENM2

Canonical Marker Genes

unknown

Rationale

LOCATION: Nerve-associated (co-localize with Schwann cells). GENE EXPRESSION: Shared Schwann markers (SCN7A, ITGA6, NGFR) plus unique markers not highly expressed in Schwann (PDGFRA, DCN, TENM2). CROSS-TISSUE INSIGHTS: Consistent with "Nerve-associated" fibroblasts annotated in Human Lung Cell Atlas in a cross-tissue integration.

Inherited from cell_type

Set of Labels Description

Aim to harmonise skin fibroblast labels across studies in both health and disease. This specific dataset includes only healthy/non-lesional cells.

Annotation Method

manual