Skin fibroblast scRNA-seq atlas in health

Main

Cell Metadata

F5: NGFR+

Full Name: Schwann-like fibroblast (NGFR+)
Closest Ontology Term: skin fibroblastCL:0002620
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: Nerve-associated fibroblast
Category Class of which the cell type is a subclass.: fibroblastCL:0000057
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: NGFR, ITGA6, SCN7A, CDH19, CLDN1, SFRP4, TENM2
Canonical Marker Genes: unknown
Rationale: LOCATION: Nerve-associated (co-localize with Schwann cells). GENE EXPRESSION: Shared Schwann markers (SCN7A, ITGA6, NGFR) plus unique markers not highly expressed in Schwann (PDGFRA, DCN, TENM2). CROSS-TISSUE INSIGHTS: Consistent with "Nerve-associated" fibroblasts annotated in Human Lung Cell Atlas in a cross-tissue integration.

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease. This specific dataset includes only healthy/non-lesional cells.
Annotation Method: manual

Full Name: Schwann-like fibroblast (NGFR+)
Closest Ontology Term: skin fibroblastCL:0002620
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: Nerve-associated fibroblast
Category Class of which the cell type is a subclass.: fibroblastCL:0000057
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: NGFR, ITGA6, SCN7A, CDH19, CLDN1, SFRP4, TENM2
Canonical Marker Genes: unknown
Rationale: LOCATION: Nerve-associated (co-localize with Schwann cells). GENE EXPRESSION: Shared Schwann markers (SCN7A, ITGA6, NGFR) plus unique markers not highly expressed in Schwann (PDGFRA, DCN, TENM2). CROSS-TISSUE INSIGHTS: Consistent with "Nerve-associated" fibroblasts annotated in Human Lung Cell Atlas in a cross-tissue integration.

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease. This specific dataset includes only healthy/non-lesional cells.
Annotation Method: manual