Skin fibroblast scRNA-seq atlas in health

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Cell Metadata

F5: RAMP1+

Full Name: Schwann-like fibroblast (RAMP1+)
Closest Ontology Term: skin fibroblastCL:0002620
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: fibroblastCL:0000057
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: RAMP1, RELN, PLEKHA6, IGFBP2, FGFBP2, SCN7A
Canonical Marker Genes: unknown
Rationale: LOCATION: Enriched near eccrine glands. GENE EXPRESSION: Shared markers with Nerve-associated F5: NGFR+ (SCN7A, FMO2, FGFBP2, OLFML2A, PEAR1), including Schwann marker SCN7A. Had highest expression of RAMP1 and CALCRL, which form the receptor complex for the neuropeptide CGRP, suggesting an interface with nerves. The function of this population is unclear. In neurofibroma, both F5: NGFR+ and F5: RAMP1+ (as well as F2/3: Perivascular) fibroblast populations were observed. CROSS-TISSUE INSIGHTS: Not observed, unlike F5: NGFR+

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease. This specific dataset includes only healthy/non-lesional cells.
Annotation Method: manual

Full Name: Schwann-like fibroblast (RAMP1+)
Closest Ontology Term: skin fibroblastCL:0002620
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: fibroblastCL:0000057
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: RAMP1, RELN, PLEKHA6, IGFBP2, FGFBP2, SCN7A
Canonical Marker Genes: unknown
Rationale: LOCATION: Enriched near eccrine glands. GENE EXPRESSION: Shared markers with Nerve-associated F5: NGFR+ (SCN7A, FMO2, FGFBP2, OLFML2A, PEAR1), including Schwann marker SCN7A. Had highest expression of RAMP1 and CALCRL, which form the receptor complex for the neuropeptide CGRP, suggesting an interface with nerves. The function of this population is unclear. In neurofibroma, both F5: NGFR+ and F5: RAMP1+ (as well as F2/3: Perivascular) fibroblast populations were observed. CROSS-TISSUE INSIGHTS: Not observed, unlike F5: NGFR+

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease. This specific dataset includes only healthy/non-lesional cells.
Annotation Method: manual