F5: RAMP1+
Full Name
- Schwann-like fibroblast (RAMP1+)
Synonyms
Terms that have the same, or nearly the same, meaning as the selected cell type.- unknown
Category
Class of which the cell type is a subclass.- fibroblastCL:0000057
Ontology Assessment
Disagreements with any aspect of the Cell Ontology.- —
Negative Marker Genes
Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.- —
Rationale
- LOCATION:
Enriched near eccrine glands.
GENE EXPRESSION:
Shared markers with Nerve-associated F5: NGFR+ (SCN7A, FMO2, FGFBP2, OLFML2A, PEAR1), including Schwann marker SCN7A. Had highest expression of RAMP1 and CALCRL, which form the receptor complex for the neuropeptide CGRP, suggesting an interface with nerves.
The function of this population is unclear. In neurofibroma, both F5: NGFR+ and F5: RAMP1+ (as well as F2/3: Perivascular) fibroblast populations were observed.
CROSS-TISSUE INSIGHTS:
Not observed, unlike F5: NGFR+
Inherited from cell_type
- Set of Labels Description
- Aim to harmonise skin fibroblast labels across studies in both health and disease. This specific dataset includes only healthy/non-lesional cells.
- Annotation Method
- manual
