F5: RAMP1+

Full Name

Schwann-like fibroblast (RAMP1+)

Closest Ontology Term

skin fibroblastCL:0002620

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

unknown

Category

Class of which the cell type is a subclass.

fibroblastCL:0000057

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

RAMP1, RELN, PLEKHA6, IGFBP2, FGFBP2, SCN7A

Canonical Marker Genes

unknown

Rationale

LOCATION: Enriched near eccrine glands. GENE EXPRESSION: Shared markers with Nerve-associated F5: NGFR+ (SCN7A, FMO2, FGFBP2, OLFML2A, PEAR1), including Schwann marker SCN7A. Had highest expression of RAMP1 and CALCRL, which form the receptor complex for the neuropeptide CGRP, suggesting an interface with nerves. The function of this population is unclear. In neurofibroma, both F5: NGFR+ and F5: RAMP1+ (as well as F2/3: Perivascular) fibroblast populations were observed. CROSS-TISSUE INSIGHTS: Not observed, unlike F5: NGFR+

Inherited from cell_type

Set of Labels Description

Aim to harmonise skin fibroblast labels across studies in both health and disease. This specific dataset includes only healthy/non-lesional cells.

Annotation Method

manual