Skin fibroblasts - Pan-disease fibroblast atlas in skin fibrosis, inflammation, and cancer

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Cell Metadata

cell_type

F3: FRC-like

Full Name: CCL19+ Fibroblast reticular-like cell
Closest Ontology Term: fibroblastic reticular cellCL:0009101
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: fibroblastic reticular cellCL:0009101
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CCL19, CD74, CH25H, TNFSF13B, IL33, HLA-DRA, IRF8, COX4I2, RBP5, ADAMDEC1, CXCL9, CXCL10, APOE, CXCL12
Canonical Marker Genes: unknown
Rationale: The F3: CCL19+ Immune-interacting population was characterised by expression of genes associated with T-reticular cells (specialised fibroblasts in lymphoid organs), including genes involved in the segregation of immune cells (CCL19, CH25H), maintenance of immune cell niches (IL33, TNFSF13B), and antigen presentation (MHC-II molecules , CD74 (Supplementary figure 1f)).(Lütge, Pikor, and Ludewig 2021) T-reticular cells modulate T-cell location and activity in lymphoid organs/structures,(Lütge, Pikor, and Ludewig 2021) suggesting a similar role for F3 fibroblasts in skin. This population also shared additional genes with F2/F3 bridge, including CXCL12, APOE, and PLA2G2A. PLA2G2A has been reported to marker a fibroblast population in cancer. APOE has been used. todescribe immune-interacting/inflammatory fibroblasts in skin more broadly. These fibroblasts were enriched in Tcell regions in our data.
Rationale DOI: 10.1111/imr.12981

Inherited from cell_type

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease.
Annotation Method: manual

F3: FRC-like

Full Name: CCL19+ Fibroblast reticular-like cell
Closest Ontology Term: fibroblastic reticular cellCL:0009101
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: fibroblastic reticular cellCL:0009101
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CCL19, CD74, CH25H, TNFSF13B, IL33, HLA-DRA, IRF8, COX4I2, RBP5, ADAMDEC1, CXCL9, CXCL10, APOE, CXCL12
Canonical Marker Genes: unknown
Rationale: The F3: CCL19+ Immune-interacting population was characterised by expression of genes associated with T-reticular cells (specialised fibroblasts in lymphoid organs), including genes involved in the segregation of immune cells (CCL19, CH25H), maintenance of immune cell niches (IL33, TNFSF13B), and antigen presentation (MHC-II molecules , CD74 (Supplementary figure 1f)).(Lütge, Pikor, and Ludewig 2021) T-reticular cells modulate T-cell location and activity in lymphoid organs/structures,(Lütge, Pikor, and Ludewig 2021) suggesting a similar role for F3 fibroblasts in skin. This population also shared additional genes with F2/F3 bridge, including CXCL12, APOE, and PLA2G2A. PLA2G2A has been reported to marker a fibroblast population in cancer. APOE has been used. todescribe immune-interacting/inflammatory fibroblasts in skin more broadly. These fibroblasts were enriched in Tcell regions in our data.
Rationale DOI: 10.1111/imr.12981

Inherited from cell_type

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease.
Annotation Method: manual