Skin fibroblasts - Pan-disease fibroblast atlas in skin fibrosis, inflammation, and cancer

Main

Cell Metadata

F8: Fascia-like myofibroblast

Full Name: Myofibroblast fascia-like
Closest Ontology Term: skin fibroblastCL:0002620
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: skin fibroblastCL:0002620
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: ACAN, ITGA10, CDH2, DPP4, CCN3
Canonical Marker Genes: unknown
Rationale: In addition to the myofibroblast gene signature (e.g. ACTA2, ASPN, SUL1, COL8A1, LRRC15), F7: Myofibroblast fascia-like had high expression of fascial fibroblast genes (DPP4, ITGA10, ACAN, and CCN3) . F7: Myofibroblast fascia-like were largely observed in Dupuyten’s contracture, a fibrotic disorder of palmar fascia. However, F7: Myofibroblast fascia-like were also observed in the non-fascial diseases, most notably keloid scarring and basal cell carcinoma. Supportive of the validity of this finding, CCN3 (an F_Fascia and F7 fibroblast marker gene) has been validated at the protein level in human keloid skin in groundbreaking work implicating fascial fibroblasts in scarring.(Correa-Gallegos et al. 2019)
Rationale DOI: 10.1038/s41586-019-1794-y

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease.
Annotation Method: manual