An integrated cell atlas of the human lung in health and disease (core)

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Cell Metadata

AT2

Ontology Term: pulmonary alveolar type 2 cellCL:0002063
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: lung type 2 cell, type 2 alveolar epithelial cell, great alveolar cell, type II alveolocyte, lung type II cell, cuboidal type II cell, granular pneumocyte, AT2, ATII, type 2 alveolocyte, type II pneumocyte, type II alveolar epithelial cell, type 2 pneumocyte, type II alveolar cell, TII
Category Class of which the cell type is a subclass.: respiratory tract secretory epithelial cellCL:0008055
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: SFTPA2, SFTPC
Canonical Marker Genes: SFTPC
Rationale: AT2 cells display very specific functional and morphological features. They synthetisize surfactant proteins. At the mRNA level, expression of SFTPA2 and SFTPC is high. Other epithelial cells from the respiratory bronchioles can also express some surfactant genes (SFTPB and SFTPC), but only AT2 cells express a combibation of several SFTP genes.

Set of Labels Description: The most fine-grained annotation available per cell.
Annotation Method: manual

Ontology Term: pulmonary alveolar type 2 cellCL:0002063
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: lung type 2 cell, type 2 alveolar epithelial cell, great alveolar cell, type II alveolocyte, lung type II cell, cuboidal type II cell, granular pneumocyte, AT2, ATII, type 2 alveolocyte, type II pneumocyte, type II alveolar epithelial cell, type 2 pneumocyte, type II alveolar cell, TII
Category Class of which the cell type is a subclass.: respiratory tract secretory epithelial cellCL:0008055
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: SFTPA2, SFTPC
Canonical Marker Genes: SFTPC
Rationale: AT2 cells display very specific functional and morphological features. They synthetisize surfactant proteins. At the mRNA level, expression of SFTPA2 and SFTPC is high. Other epithelial cells from the respiratory bronchioles can also express some surfactant genes (SFTPB and SFTPC), but only AT2 cells express a combibation of several SFTP genes.

Set of Labels Description: The most fine-grained annotation available per cell.
Annotation Method: manual