An integrated cell atlas of the human lung in health and disease (core)

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Cell Metadata

Suprabasal

Ontology Term: respiratory tract suprabasal cellCL:4033048
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: respiratory parabasal cell, respiratory suprabasal progenitor cell, respiratory suprabasal cell
Category Class of which the cell type is a subclass.: progenitor cellCL:0011026
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: KRT5, SCL25A5, SERPINB13, KRT19
Canonical Marker Genes: unknown
Rationale: Suprabasal cells exhibit both morphological and molecular similarities to basal cells. However, within the epithelium, they occupy a parabasal position, meaning their nuclei are situated between those of basal and luminal cells. Their gene expression profile closely resembles that of basal cells, forming a continuum between basal and secretory cells. Suprabasal cells can be distinguished from basal cells by the absence or low expression of the TP63 gene, serving as a negative marker. While their KRT5 expression is comparable to that of basal cells, they exhibit little to no TP63 expression. Additionally, they show slightly higher KRT8 expression than basal cells. In contrast to secretory cells, suprabasal cells maintain higher KRT5 expression and do not express secretory cell-specific genes. Their gene expression profile
Rationale DOI: 10.1242/dev.116855

Set of Labels Description: The most fine-grained annotation available per cell.
Annotation Method: manual

Ontology Term: respiratory tract suprabasal cellCL:4033048
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: respiratory parabasal cell, respiratory suprabasal progenitor cell, respiratory suprabasal cell
Category Class of which the cell type is a subclass.: progenitor cellCL:0011026
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: KRT5, SCL25A5, SERPINB13, KRT19
Canonical Marker Genes: unknown
Rationale: Suprabasal cells exhibit both morphological and molecular similarities to basal cells. However, within the epithelium, they occupy a parabasal position, meaning their nuclei are situated between those of basal and luminal cells. Their gene expression profile closely resembles that of basal cells, forming a continuum between basal and secretory cells. Suprabasal cells can be distinguished from basal cells by the absence or low expression of the TP63 gene, serving as a negative marker. While their KRT5 expression is comparable to that of basal cells, they exhibit little to no TP63 expression. Additionally, they show slightly higher KRT8 expression than basal cells. In contrast to secretory cells, suprabasal cells maintain higher KRT5 expression and do not express secretory cell-specific genes. Their gene expression profile
Rationale DOI: 10.1242/dev.116855

Set of Labels Description: The most fine-grained annotation available per cell.
Annotation Method: manual