An integrated cell atlas of the human lung in health and disease (core)

Main

Cell Metadata

Basal resting

Ontology Term: basal cellCL:0000646
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: epithelial fate stem cellCL:0000036
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: KRT5, TP63, DLK2
Canonical Marker Genes: unknown
Rationale: Basal epithelial cells located beneath the luminal cells and occupying the basal layer of the airway epithelium. Function as precursor cells that give rise to other epithelial cell types during tissue maintenance and regeneration. These are termed "resting" because there are distinct subpopulations defined by their functional roles and expression of specific molecular markers. Basal resting cells express canonical basal cell markers (KRT5 and TP63), but not proliferation markers (MKi67), or repair (KRT14) markers which can be found in basal cells.
Rationale DOI: https://doi.org/10.7554/eLife.80083 https://doi.org/10.1016/j.celrep.2015.06.011 https://doi.org/10.1038/s41586-018-0394-6 https://doi.org/10.1152/ajplung.00155.2003 https://doi.org/10.1165/rcmb.2010-0283OC

Set of Labels Description: The most fine-grained annotation available per cell.
Annotation Method: manual

Ontology Term: basal cellCL:0000646
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: epithelial fate stem cellCL:0000036
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: KRT5, TP63, DLK2
Canonical Marker Genes: unknown
Rationale: Basal epithelial cells located beneath the luminal cells and occupying the basal layer of the airway epithelium. Function as precursor cells that give rise to other epithelial cell types during tissue maintenance and regeneration. These are termed "resting" because there are distinct subpopulations defined by their functional roles and expression of specific molecular markers. Basal resting cells express canonical basal cell markers (KRT5 and TP63), but not proliferation markers (MKi67), or repair (KRT14) markers which can be found in basal cells.
Rationale DOI: https://doi.org/10.7554/eLife.80083 https://doi.org/10.1016/j.celrep.2015.06.011 https://doi.org/10.1038/s41586-018-0394-6 https://doi.org/10.1152/ajplung.00155.2003 https://doi.org/10.1165/rcmb.2010-0283OC

Set of Labels Description: The most fine-grained annotation available per cell.
Annotation Method: manual