An integrated cell atlas of the human lung in health and disease (core)

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Cell Metadata

Multiciliated (non-nasal)

Ontology Term: multiciliated columnar cell of tracheobronchial treeCL:0002145
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: ciliated columnar cell of tracheobronchial tree
Category Class of which the cell type is a subclass.: respiratory tract multiciliated cellCL:4030034
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CIMAP3, FOXJ1
Canonical Marker Genes: unknown
Rationale: Multiciliated cells are luminal columnar epithelial cells prensent from the nose to the bronchioles. They bear up to 300 motile cilia on their apical surface. They can be identified by many specific marker genes such as FOXJ1, which is a master transcription factor of multiciliogenesis. FOXJ1 is also expressed at the pre-multiciliated stage where cells amplify their centrioles, this stage is also termed "deuterosomal". Multicilitaed cells express late multiciliogenesis markers such as CAPS, ROPNL1, RSPH1. Multiciliated (non-nasal) have a gene expression profile which is very similar to that of nasal multiciliated but they do not express nasal specific genes such as SIX3, OTX2 and PAX7.
Rationale DOI: https://doi.org/10.1164/rccm.201911-2199oc

Set of Labels Description: The most fine-grained annotation available per cell.
Annotation Method: manual

Ontology Term: multiciliated columnar cell of tracheobronchial treeCL:0002145
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: ciliated columnar cell of tracheobronchial tree
Category Class of which the cell type is a subclass.: respiratory tract multiciliated cellCL:4030034
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CIMAP3, FOXJ1
Canonical Marker Genes: unknown
Rationale: Multiciliated cells are luminal columnar epithelial cells prensent from the nose to the bronchioles. They bear up to 300 motile cilia on their apical surface. They can be identified by many specific marker genes such as FOXJ1, which is a master transcription factor of multiciliogenesis. FOXJ1 is also expressed at the pre-multiciliated stage where cells amplify their centrioles, this stage is also termed "deuterosomal". Multicilitaed cells express late multiciliogenesis markers such as CAPS, ROPNL1, RSPH1. Multiciliated (non-nasal) have a gene expression profile which is very similar to that of nasal multiciliated but they do not express nasal specific genes such as SIX3, OTX2 and PAX7.
Rationale DOI: https://doi.org/10.1164/rccm.201911-2199oc

Set of Labels Description: The most fine-grained annotation available per cell.
Annotation Method: manual