An integrated cell atlas of the human lung in health and disease (core)

Goblet (nasal)

Ontology Term: nasal mucosa goblet cellCL:0002480
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: respiratory tract goblet cellCL:0002370
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CEACAM5, MUC5AC, LYZ, SCGB3A1
Canonical Marker Genes: unknown
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: Goblet cells are luminal cells of the epithelium secreting mucus. Theses have been termed nasal goblet cells because they expresss mainly MUC5AC as secreting mucin, and not MUC5B which can be found goblet cells from the submucosal glands but also from surface epithelial goblet cells from pulmonary airways. Theu can also be distinguished from pulmonary airways goblet cells by the expression of developmental origin genes such as SIX3, PAX7, OTX2.
Rationale DOI: https://doi.org/10.1164/rccm.201911-2199oc

Set of Labels Description: The most fine-grained annotation available per cell.
Annotation Method: manual