An integrated cell atlas of the human lung in health and disease (core)

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Cell Metadata

Multiciliated (nasal)

Ontology Term: multiciliated epithelial cellCL:0005012
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: ciliated epithelial cellCL:0000067
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CIMAP3, FOXJ1, SIX3
Canonical Marker Genes: unknown
Rationale: Multiciliated cells are luminal columnar epithelial cells prensent from the nose to the bronchioles. They bear up to 300 motile cilia on their apical surface. They can be identified by many specific marker genes such as FOXJ1, which is a master transcription factor of multiciliogenesis. FOXJ1 is also expressed at the pre-multiciliated stage where cells amplify their centrioles, this stage is also termed "deuterosomal". Multicilitaed cells express late multiciliogenesis markers such as CAPS, ROPNL1, RSPH1. Multiciliated (nasal) have a gene expression profile which is very similar to that of non-nasal multiciliated but they express nasal specific genes such as SIX3, OTX2 and PAX7.
Rationale DOI: https://doi.org/10.1164/rccm.201911-2199oc

Set of Labels Description: The most fine-grained annotation available per cell.
Annotation Method: manual

Ontology Term: multiciliated epithelial cellCL:0005012
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: ciliated epithelial cellCL:0000067
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CIMAP3, FOXJ1, SIX3
Canonical Marker Genes: unknown
Rationale: Multiciliated cells are luminal columnar epithelial cells prensent from the nose to the bronchioles. They bear up to 300 motile cilia on their apical surface. They can be identified by many specific marker genes such as FOXJ1, which is a master transcription factor of multiciliogenesis. FOXJ1 is also expressed at the pre-multiciliated stage where cells amplify their centrioles, this stage is also termed "deuterosomal". Multicilitaed cells express late multiciliogenesis markers such as CAPS, ROPNL1, RSPH1. Multiciliated (nasal) have a gene expression profile which is very similar to that of non-nasal multiciliated but they express nasal specific genes such as SIX3, OTX2 and PAX7.
Rationale DOI: https://doi.org/10.1164/rccm.201911-2199oc

Set of Labels Description: The most fine-grained annotation available per cell.
Annotation Method: manual