An integrated cell atlas of the human lung in health and disease (core)

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Cell Metadata

Goblet (bronchial)

Ontology Term: bronchial goblet cellCL:1000312
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: goblet cell of epithelium of bronchus
Category Class of which the cell type is a subclass.: tracheobronchial goblet cellCL:0019003
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: SCGB1A1, MUC5AC, MUC5B
Canonical Marker Genes: unknown
Rationale: Goblet cells are luminal cells of the epithelium secreting mucus. These have been termed bronchial goblet cells because they express MUC5AC as secreting mucin, and but also MUC5B in some of goblet cells which can be found at the surface epithelium pulmonary airways. They can also be distinguished from nasal goblet cells by the absence of expression of nasal developmental origin genes such as SIX3, PAX7, OTX2.
Rationale DOI: https://doi.org/10.1164/rccm.201911-2199oc

Set of Labels Description: The most fine-grained annotation available per cell.
Annotation Method: manual

Ontology Term: bronchial goblet cellCL:1000312
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: goblet cell of epithelium of bronchus
Category Class of which the cell type is a subclass.: tracheobronchial goblet cellCL:0019003
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: SCGB1A1, MUC5AC, MUC5B
Canonical Marker Genes: unknown
Rationale: Goblet cells are luminal cells of the epithelium secreting mucus. These have been termed bronchial goblet cells because they express MUC5AC as secreting mucin, and but also MUC5B in some of goblet cells which can be found at the surface epithelium pulmonary airways. They can also be distinguished from nasal goblet cells by the absence of expression of nasal developmental origin genes such as SIX3, PAX7, OTX2.
Rationale DOI: https://doi.org/10.1164/rccm.201911-2199oc

Set of Labels Description: The most fine-grained annotation available per cell.
Annotation Method: manual