HCA Gut Cell Atlas v1 Lymphoid Lineage

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Cell Metadata

CD4 Tfh

Ontology Term: T follicular helper cellCL:0002038
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: Tfh, follicular helper CD4 T cell
Category Class of which the cell type is a subclass.: CD4-positive, alpha-beta T cellCL:0000624
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: BCL6, CXCR5, CD40LG, CXCL13
Canonical Marker Genes: BCL6, CXCR5, PDCD1
Rationale: CD40LG and ICOS are used to annotate Tfh in this data. These are also found in larger clusters of CD4 naive cells

Set of Labels Description: Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering
Annotation Method: both
Algorithm Name: scVI
Algorithm Version: 1.3.2
Algorithm URL: https://github.com/scverse/scvi-tools

Ontology Term: T follicular helper cellCL:0002038
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: Tfh, follicular helper CD4 T cell
Category Class of which the cell type is a subclass.: CD4-positive, alpha-beta T cellCL:0000624
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: BCL6, CXCR5, CD40LG, CXCL13
Canonical Marker Genes: BCL6, CXCR5, PDCD1
Rationale: CD40LG and ICOS are used to annotate Tfh in this data. These are also found in larger clusters of CD4 naive cells

Set of Labels Description: Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering
Annotation Method: both
Algorithm Name: scVI
Algorithm Version: 1.3.2
Algorithm URL: https://github.com/scverse/scvi-tools