Abdominal subcutaneous adipose tissue (Loft et al., 2026, Nature Met)

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Cell Metadata

ASPCs

Ontology Term: fibro/adipogenic progenitor cellCL:0009099
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: fibro/adipogenic progenitor, mesenchymal stem cell of adipose tissue, preadipocyte
Category Class of which the cell type is a subclass.: progenitor cellCL:0011026
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PDGFRA, DCN
Canonical Marker Genes: PDGFRA, DCN
Rationale: PDGFRA and DCN are commonly used markers of adipose-derived stromal/progenitor cells (ASPCs). PDGFRA identifies mesenchymal stromal progenitors within adipose tissue and is enriched in cells with adipogenic potential. DCN (decorin) is an extracellular matrix proteoglycan highly expressed by stromal fibroblast-like cells and reflects the mesenchymal, matrix-producing identity of ASPCs. PDGFRA and DCN distinguish stromal/progenitor populations from mature adipocytes and endothelial or immune cells, supporting their use as markers of ASPCs.
Rationale DOI: 10.1038/s42255-025-01296-9

Set of Labels Description: Annotation of all broad canonical cell populations present in AT were based on previously described markers from Loft et al. 2026 (PMID: 40360756).
Annotation Method: manual

Ontology Term: fibro/adipogenic progenitor cellCL:0009099
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: fibro/adipogenic progenitor, mesenchymal stem cell of adipose tissue, preadipocyte
Category Class of which the cell type is a subclass.: progenitor cellCL:0011026
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PDGFRA, DCN
Canonical Marker Genes: PDGFRA, DCN
Rationale: PDGFRA and DCN are commonly used markers of adipose-derived stromal/progenitor cells (ASPCs). PDGFRA identifies mesenchymal stromal progenitors within adipose tissue and is enriched in cells with adipogenic potential. DCN (decorin) is an extracellular matrix proteoglycan highly expressed by stromal fibroblast-like cells and reflects the mesenchymal, matrix-producing identity of ASPCs. PDGFRA and DCN distinguish stromal/progenitor populations from mature adipocytes and endothelial or immune cells, supporting their use as markers of ASPCs.
Rationale DOI: 10.1038/s42255-025-01296-9

Set of Labels Description: Annotation of all broad canonical cell populations present in AT were based on previously described markers from Loft et al. 2026 (PMID: 40360756).
Annotation Method: manual