Abdominal subcutaneous adipose tissue (Loft et al., 2026, Nature Met)

Main

Cell Metadata

ECs

Ontology Term: endothelial cellCL:0000115
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: endotheliocyte
Category Class of which the cell type is a subclass.: eukaryotic cellCL:0000255
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MECOM, ADGRL4
Canonical Marker Genes: MECOM, ADGRL4
Rationale: ADGRL4 (ELTD1) is an adhesion G protein–coupled receptor selectively expressed in vascular endothelial cells and is associated with angiogenic activity. MECOM is enriched in endothelial populations and has been implicated in endothelial cell identity and vascular development. MECOM and ADGRL4 support the identification of endothelial cells and help distinguish them from surrounding stromal and parenchymal cell types.

Set of Labels Description: Annotation of all broad canonical cell populations present in AT were based on previously described markers from Loft et al. 2026 (PMID: 40360756).
Annotation Method: manual

Ontology Term: endothelial cellCL:0000115
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: endotheliocyte
Category Class of which the cell type is a subclass.: eukaryotic cellCL:0000255
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MECOM, ADGRL4
Canonical Marker Genes: MECOM, ADGRL4
Rationale: ADGRL4 (ELTD1) is an adhesion G protein–coupled receptor selectively expressed in vascular endothelial cells and is associated with angiogenic activity. MECOM is enriched in endothelial populations and has been implicated in endothelial cell identity and vascular development. MECOM and ADGRL4 support the identification of endothelial cells and help distinguish them from surrounding stromal and parenchymal cell types.

Set of Labels Description: Annotation of all broad canonical cell populations present in AT were based on previously described markers from Loft et al. 2026 (PMID: 40360756).
Annotation Method: manual