Abdominal subcutaneous adipose tissue (Loft et al., 2026, Nature Met)

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Cell Metadata

Myeloid immune cells

Ontology Term: myeloid cellCL:0000763
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: hematopoietic cellCL:0000988
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MRC1, F13A1
Canonical Marker Genes: MRC1, F13A1
Rationale: MRC1 (CD206) is a C-type lectin receptor expressed by macrophages and monocyte-derived cells, particularly those with a tissue-resident or alternatively activated phenotype. F13A1, encoding coagulation factor XIII A chain, is enriched in monocytes and macrophages and reflects myeloid lineage identity. MRC1 and F13A1 support the identification of myeloid immune cell populations and distinguish them from non-immune stromal and parenchymal cells.
Rationale DOI: 10.1038/s42255-025-01296-9

Set of Labels Description: Annotation of all broad canonical cell populations present in AT were based on previously described markers from Loft et al. 2026 (PMID: 40360756).
Annotation Method: manual

Ontology Term: myeloid cellCL:0000763
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: hematopoietic cellCL:0000988
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MRC1, F13A1
Canonical Marker Genes: MRC1, F13A1
Rationale: MRC1 (CD206) is a C-type lectin receptor expressed by macrophages and monocyte-derived cells, particularly those with a tissue-resident or alternatively activated phenotype. F13A1, encoding coagulation factor XIII A chain, is enriched in monocytes and macrophages and reflects myeloid lineage identity. MRC1 and F13A1 support the identification of myeloid immune cell populations and distinguish them from non-immune stromal and parenchymal cells.
Rationale DOI: 10.1038/s42255-025-01296-9

Set of Labels Description: Annotation of all broad canonical cell populations present in AT were based on previously described markers from Loft et al. 2026 (PMID: 40360756).
Annotation Method: manual