Abdominal subcutaneous adipose tissue (Loft et al., 2026, Nature Met)

Lymphatic ECs

Ontology Term

endothelial cell of lymphatic vesselCL:0002138

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

LEC, lymphatic endothelial cell

Category

Class of which the cell type is a subclass.

endothelial cellCL:0000115

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

PKHD1L1, PROX1

Canonical Marker Genes

PKHD1L1, PROX1

Rationale

PROX1 is a master transcriptional regulator of lymphatic endothelial cell fate and is essential for lymphatic specification and maintenance. PKHD1L1 is enriched in lymphatic endothelial cells and has been identified as a marker distinguishing lymphatic from blood vascular endothelium.

Rationale DOI

10.1038/s42255-025-01296-9

Inherited from author_cell_type

Set of Labels Description

Annotation of all broad canonical cell populations present in AT were based on previously described markers from Loft et al. 2026 (PMID: 40360756).

Annotation Method

manual

• v1 Single-cell-resolved transcriptional dynamics of human subcutaneous adipose tissue during lifestyle- and bariatric surgery-induced weight loss
• Abdominal subcutaneous adipose tissue (Loft et al., 2026, Nature Met)