The skeletal muscle response to high‐intensity training assessed by single‐nucleus RNA‐sequencing is blunted in individuals with type 2 diabetes

snRNAseq on trained and untrained human skeletal muscle from individuals with type 2 diabetes and control

Single-nuclei RNA sequencing (snRNA-seq) data of human muscle cells. The samples are a part of a study investigating the effect of one-legged high-intensity interval training (HIIT) on the nuclear transcriptional response in skeletal muscle. The HIIT was done on one leg on a cycle ergometer, and vastus lateralis muscle biopsies were obtained from both the untrained and trained leg following the two weeks training protocol. The study contains samples from 9 people with Type 2 Diabetes (T2D) and 10 samples from a Body Mass Index (BMI) and age matched control group without diabetes. The experimental study is described in: Dela et al., Acta Physiol, 2019. The snRNA-seq data contains nuclei isolated from 38 available biopsies with the following conditions: Control-Trained, Control-Untrained, Diabetes-Trained, Diabetes-Untrained.