Single-nucleus RNA-seq of Asian Skeletal Muscle Reveals Ancestry-specific Regulatory Programs Across Metabolic States

muscle fiber type 2

Ontology Term

fast muscle cellCL:0000190

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

type II muscle fiber, fast-twitch fiber, type 2 myonuclei

Category

Class of which the cell type is a subclass.

cell of skeletal muscleCL:0000188

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

TNNT3, TTN, ATP2A1, TNNI2, MYH2, MYH1

Canonical Marker Genes

TNNT3, TTN, ATP2A1, TNNI2, MYH2, MYH1

Rationale

Annotated based on canonical fast/type II myofiber markers from snRNA-seq differential expression analysis. High expression of TNNT3, TTN, ATP2A1 (SERCA1), TNNI2.

Inherited from author_cell_type

Set of Labels Description

Cell annotations are based on a Level 1 annotation scheme, assigning the most appropriate broad cell type label to each of the 11 clusters identified during integration.

Annotation Method

manual