Single-nucleus RNA-seq of Asian Skeletal Muscle Reveals Ancestry-specific Regulatory Programs Across Metabolic States

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Cell Metadata

muscle fiber type 2

Ontology Term: fast muscle cellCL:0000190
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: type II muscle fiber, fast-twitch fiber, type 2 myonuclei
Category Class of which the cell type is a subclass.: cell of skeletal muscleCL:0000188
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: TNNT3, TTN, ATP2A1, TNNI2, MYH2, MYH1
Canonical Marker Genes: TNNT3, TTN, ATP2A1, TNNI2, MYH2, MYH1
Rationale: Annotated based on canonical fast/type II myofiber markers from snRNA-seq differential expression analysis. High expression of TNNT3, TTN, ATP2A1 (SERCA1), TNNI2.

Set of Labels Description: Cell annotations are based on a Level 1 annotation scheme, assigning the most appropriate broad cell type label to each of the 11 clusters identified during integration.
Annotation Method: manual

Ontology Term: fast muscle cellCL:0000190
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: type II muscle fiber, fast-twitch fiber, type 2 myonuclei
Category Class of which the cell type is a subclass.: cell of skeletal muscleCL:0000188
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: TNNT3, TTN, ATP2A1, TNNI2, MYH2, MYH1
Canonical Marker Genes: TNNT3, TTN, ATP2A1, TNNI2, MYH2, MYH1
Rationale: Annotated based on canonical fast/type II myofiber markers from snRNA-seq differential expression analysis. High expression of TNNT3, TTN, ATP2A1 (SERCA1), TNNI2.

Set of Labels Description: Cell annotations are based on a Level 1 annotation scheme, assigning the most appropriate broad cell type label to each of the 11 clusters identified during integration.
Annotation Method: manual