HCA Gut Cell Atlas v1 Epithelial Lineage

Epithelial Stem Cells (LGR5+)

Ontology Term: intestinal crypt stem cellCL:0002250
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: epithelial cellCL:0000066
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: LGR5
Canonical Marker Genes: LGR5, OLFM4
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: LGR5 expression is a clear determinant of epith stem cells

Set of Labels Description: Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering
Annotation Method: algorithmic