Human Gut Cell Atlas (HGCA) v1 - All Cells

CD4 Th17

Ontology Term

T-helper 17 cellCL:0000899

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

Th17 CD4 T cell, Th17

Category

Class of which the cell type is a subclass.

CD4-positive, alpha-beta T cellCL:0000624

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

RORC, IL17A, IL22, IL21, CSF2, IL23R

Canonical Marker Genes

RORC, IL17A, CCR6

Rationale

Since both ILC3s and Th17 express RORC and IL7R, these can be difficult to separate. Th17 were annotated when larger clusters of naive T cells showed a clear IL7R and RORC expressing subcluster

Inherited from hgca_celltype_v0

Set of Labels Description

Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering

Annotation Method

both

Algorithm Name

scVI

Algorithm Version

1.3.2

Algorithm URL

https://github.com/scverse/scvi-tools