Human Adipose Tissue Atlas v1.0 — Cervical Subcutaneous WAT

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Cell Metadata

EPHA3⁺ ASPCs

Ontology Term: fibro/adipogenic progenitor cellCL:0009099
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: mesenchymal stem cell of adipose tissue, preadipocyte
Category Class of which the cell type is a subclass.: progenitor cellCL:0011026
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PDGFRA, DCN, EPHA3
Canonical Marker Genes: PDGFRA, DCN, EPHA3
Rationale: PDGFRA and DCN (decorin) are general ASPC/stromal markers broadly expressed across adipose stromal and progenitor cell populations. EPHA3 (ephrin type-A receptor 3) is the defining marker of this subpopulation, distinguishing EPHA3⁺ ASPCs from other ASPC subtypes. This population resembles an adipogenesis-regulatory cell population previously reported in mice. Together these markers identify a distinct ASPC subpopulation within the broader stromal compartment.
Rationale DOI: 10.1038/s42255-025-01433-4

Ontology Term: fibro/adipogenic progenitor cellCL:0009099
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: mesenchymal stem cell of adipose tissue, preadipocyte
Category Class of which the cell type is a subclass.: progenitor cellCL:0011026
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PDGFRA, DCN, EPHA3
Canonical Marker Genes: PDGFRA, DCN, EPHA3
Rationale: PDGFRA and DCN (decorin) are general ASPC/stromal markers broadly expressed across adipose stromal and progenitor cell populations. EPHA3 (ephrin type-A receptor 3) is the defining marker of this subpopulation, distinguishing EPHA3⁺ ASPCs from other ASPC subtypes. This population resembles an adipogenesis-regulatory cell population previously reported in mice. Together these markers identify a distinct ASPC subpopulation within the broader stromal compartment.
Rationale DOI: 10.1038/s42255-025-01433-4