Human Adipose Tissue Atlas v1.0 — Cervical Subcutaneous WAT

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Cell Metadata

Venous ECs

Ontology Term: vein endothelial cellCL:0002543
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: venous endothelial cell, endothelial cell of vein
Category Class of which the cell type is a subclass.: endothelial cellCL:0000115
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PECAM1, MECOM, CDH5, ENPEP, ACKR1
Canonical Marker Genes: PECAM1, MECOM, CDH5, ENPEP, ACKR1
Rationale: PECAM1 (CD31) and CDH5 (VE-cadherin) are pan-endothelial markers confirming endothelial identity, while MECOM and ENPEP further support this. ACKR1 (atypical chemokine receptor 1, also known as DARC) shows enriched expression in venous endothelial cells and is involved in chemokine scavenging. Together these markers identify venous ECs and distinguish them from capillary, arterial, and lymphatic endothelial subtypes.
Rationale DOI: 10.1038/s42255-025-01296-9

Ontology Term: vein endothelial cellCL:0002543
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: venous endothelial cell, endothelial cell of vein
Category Class of which the cell type is a subclass.: endothelial cellCL:0000115
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PECAM1, MECOM, CDH5, ENPEP, ACKR1
Canonical Marker Genes: PECAM1, MECOM, CDH5, ENPEP, ACKR1
Rationale: PECAM1 (CD31) and CDH5 (VE-cadherin) are pan-endothelial markers confirming endothelial identity, while MECOM and ENPEP further support this. ACKR1 (atypical chemokine receptor 1, also known as DARC) shows enriched expression in venous endothelial cells and is involved in chemokine scavenging. Together these markers identify venous ECs and distinguish them from capillary, arterial, and lymphatic endothelial subtypes.
Rationale DOI: 10.1038/s42255-025-01296-9