Human Adipose Tissue Atlas v1.0 — Vascular cells

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Cell Metadata

SMCs

Ontology Term: smooth muscle cellCL:0000192
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: SMCs, non-striated muscle cell, myocytes smooth muscle, smooth muscle fiber
Category Class of which the cell type is a subclass.: mural cellCL:0008034
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MYOCD, MYH11
Canonical Marker Genes: MYOCD, MYH11
Rationale: MYOCD (myocardin) is a transcription factor driving smooth muscle cell differentiation and is enriched in smooth muscle cells. MYH11 (smooth muscle myosin heavy chain) is a contractile protein with enriched expression in mature smooth muscle cells. Together these markers reliably identify smooth muscle cells within the mural cell compartment and distinguish them from pericytes and other stromal populations.
Rationale DOI: 10.1038/s42255-025-01296-9

Ontology Term: smooth muscle cellCL:0000192
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: SMCs, non-striated muscle cell, myocytes smooth muscle, smooth muscle fiber
Category Class of which the cell type is a subclass.: mural cellCL:0008034
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MYOCD, MYH11
Canonical Marker Genes: MYOCD, MYH11
Rationale: MYOCD (myocardin) is a transcription factor driving smooth muscle cell differentiation and is enriched in smooth muscle cells. MYH11 (smooth muscle myosin heavy chain) is a contractile protein with enriched expression in mature smooth muscle cells. Together these markers reliably identify smooth muscle cells within the mural cell compartment and distinguish them from pericytes and other stromal populations.
Rationale DOI: 10.1038/s42255-025-01296-9