Human Adipose Tissue Atlas v1.0 — ASPCs

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Cell Metadata

TENM2⁺ ASPCs

Ontology Term: fibro/adipogenic progenitor cellCL:0009099
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: mesenchymal stem cell of adipose tissue, preadipocyte
Category Class of which the cell type is a subclass.: progenitor cellCL:0011026
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: DCN, TENM2, SLC22A3, ITGA6
Canonical Marker Genes: DCN, TENM2, SLC22A3, ITGA6
Rationale: DCN (decorin) is a stromal/fibroblast marker broadly expressed in connective tissue. TENM2 (teneurin-2) is a transmembrane protein involved in neural circuit organization and cell-cell signaling. SLC22A3 is an organic cation transporter with enriched expression in specific stromal subpopulations. ITGA6 (integrin alpha-6) marks cells associated with basement membrane adhesion and has been found enriched in fibroblasts surrounding peripheral nerves in tendon and muscle, suggesting a perineural identity. Together, these markers characterize a stromal/ASPC subpopulation with perineural localization, here referred to as TENM2⁺ ASPCs.
Rationale DOI: 10.1152/ajpcell.00838.2025

Ontology Term: fibro/adipogenic progenitor cellCL:0009099
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: mesenchymal stem cell of adipose tissue, preadipocyte
Category Class of which the cell type is a subclass.: progenitor cellCL:0011026
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: DCN, TENM2, SLC22A3, ITGA6
Canonical Marker Genes: DCN, TENM2, SLC22A3, ITGA6
Rationale: DCN (decorin) is a stromal/fibroblast marker broadly expressed in connective tissue. TENM2 (teneurin-2) is a transmembrane protein involved in neural circuit organization and cell-cell signaling. SLC22A3 is an organic cation transporter with enriched expression in specific stromal subpopulations. ITGA6 (integrin alpha-6) marks cells associated with basement membrane adhesion and has been found enriched in fibroblasts surrounding peripheral nerves in tendon and muscle, suggesting a perineural identity. Together, these markers characterize a stromal/ASPC subpopulation with perineural localization, here referred to as TENM2⁺ ASPCs.
Rationale DOI: 10.1152/ajpcell.00838.2025