Human Adipose Tissue Atlas v1.0 — ASPCs

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Cell Metadata

ASPCs

Ontology Term: fibro/adipogenic progenitor cellCL:0009099
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: mesenchymal stem cell of adipose tissue, preadipocyte
Category Class of which the cell type is a subclass.: progenitor cellCL:0011026
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PDGFRA, DCN
Canonical Marker Genes: PDGFRA, DCN
Rationale: PDGFRA and DCN (decorin) are pan-ASPC markers broadly expressed across all adipose stromal and progenitor cell subpopulations. Together these markers define the ASPC compartment encompassing DPP4⁺, EPHA3⁺, IGFBP2⁺, PPARG⁺, and TENM2⁺ subtypes.
Rationale DOI: 10.1038/s42255-025-01296-9

Set of Labels Description: Level 2 cell type labels (represents broad clusters most studies tend to identify).
Annotation Method: manual

Ontology Term: fibro/adipogenic progenitor cellCL:0009099
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: mesenchymal stem cell of adipose tissue, preadipocyte
Category Class of which the cell type is a subclass.: progenitor cellCL:0011026
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PDGFRA, DCN
Canonical Marker Genes: PDGFRA, DCN
Rationale: PDGFRA and DCN (decorin) are pan-ASPC markers broadly expressed across all adipose stromal and progenitor cell subpopulations. Together these markers define the ASPC compartment encompassing DPP4⁺, EPHA3⁺, IGFBP2⁺, PPARG⁺, and TENM2⁺ subtypes.
Rationale DOI: 10.1038/s42255-025-01296-9

Set of Labels Description: Level 2 cell type labels (represents broad clusters most studies tend to identify).
Annotation Method: manual