Human Adipose Tissue Atlas v1.0 — Abdominal Visceral WAT

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Cell Metadata

B cells

Ontology Term: B cellCL:0000236
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: B lymphocyte, B-lymphocyte, B-cell
Category Class of which the cell type is a subclass.: lymphocyteCL:0000542
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MS4A1, CD79A, IGKC, JCHAIN, MZB1
Canonical Marker Genes: MS4A1, CD79A, IGKC, JCHAIN, MZB1
Rationale: MS4A1 (CD20) and CD79A confirm B cell lineage identity, with IGKC reflecting active immunoglobulin expression. JCHAIN and MZB1 mark antibody-secreting plasma cells, which are included in this compartment as terminally differentiated B cell-derived populations. Together these markers define the B cell compartment encompassing naive B cells and plasma cells.
Rationale DOI: 10.1038/s42255-025-01296-9 10.57785/e9e1-wh09

Set of Labels Description: Level 2 cell type labels (represents broad clusters most studies tend to identify).
Annotation Method: manual

Ontology Term: B cellCL:0000236
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: B lymphocyte, B-lymphocyte, B-cell
Category Class of which the cell type is a subclass.: lymphocyteCL:0000542
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MS4A1, CD79A, IGKC, JCHAIN, MZB1
Canonical Marker Genes: MS4A1, CD79A, IGKC, JCHAIN, MZB1
Rationale: MS4A1 (CD20) and CD79A confirm B cell lineage identity, with IGKC reflecting active immunoglobulin expression. JCHAIN and MZB1 mark antibody-secreting plasma cells, which are included in this compartment as terminally differentiated B cell-derived populations. Together these markers define the B cell compartment encompassing naive B cells and plasma cells.
Rationale DOI: 10.1038/s42255-025-01296-9 10.57785/e9e1-wh09

Set of Labels Description: Level 2 cell type labels (represents broad clusters most studies tend to identify).
Annotation Method: manual