Human Adipose Tissue Atlas v1.0 — Abdominal Visceral WAT

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Cell Metadata

CD4⁺ T cells

Ontology Term: CD4-positive, alpha-beta T cellCL:0000624
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: CD4-positive, alpha-beta T-cell, alpha-beta T lymphocyte, alpha-beta T-lymphocyte
Category Class of which the cell type is a subclass.: T cellCL:0000084
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CD3D, CD3E, CD2, CD4, CD40LG
Canonical Marker Genes: CD3D, CD3E, CD2, CD4, CD40LG
Rationale: CD3D and CD3E are components of the T cell receptor signaling complex, confirming T cell lineage identity. CD4 is a surface co-receptor defining the CD4⁺ T cell lineage. CD2 is a surface adhesion molecule broadly expressed on T cells and NK cells, supporting T cell activation. CD40LG (CD40 ligand) is expressed on activated CD4⁺ T cells and is involved in T cell-B cell interactions. Together these markers identify CD4⁺ T cells and distinguish them from CD8⁺ and regulatory T cell populations.
Rationale DOI: 10.57785/e9e1-wh09 10.1038/s42255-025-01296-9

Ontology Term: CD4-positive, alpha-beta T cellCL:0000624
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: CD4-positive, alpha-beta T-cell, alpha-beta T lymphocyte, alpha-beta T-lymphocyte
Category Class of which the cell type is a subclass.: T cellCL:0000084
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CD3D, CD3E, CD2, CD4, CD40LG
Canonical Marker Genes: CD3D, CD3E, CD2, CD4, CD40LG
Rationale: CD3D and CD3E are components of the T cell receptor signaling complex, confirming T cell lineage identity. CD4 is a surface co-receptor defining the CD4⁺ T cell lineage. CD2 is a surface adhesion molecule broadly expressed on T cells and NK cells, supporting T cell activation. CD40LG (CD40 ligand) is expressed on activated CD4⁺ T cells and is involved in T cell-B cell interactions. Together these markers identify CD4⁺ T cells and distinguish them from CD8⁺ and regulatory T cell populations.
Rationale DOI: 10.57785/e9e1-wh09 10.1038/s42255-025-01296-9