Human Adipose Tissue Atlas v1.0 — Abdominal Visceral WAT

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Cell Metadata

Lymphatic ECs

Ontology Term: endothelial cell of lymphatic vesselCL:0002138
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: LEC, lymphatic endothelial cell
Category Class of which the cell type is a subclass.: endothelial cellCL:0000115
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PECAM1, MECOM, CDH5, ENPEP, PROX1, LYVE1
Canonical Marker Genes: PECAM1, MECOM, CDH5, ENPEP, PROX1, LYVE1
Rationale: PECAM1 (CD31) and CDH5 (VE-cadherin) are pan-endothelial markers confirming endothelial identity, while MECOM and ENPEP further support this. PROX1 is a transcription factor required for lymphatic endothelial cell specification and maintenance, and LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1) is expressed on the surface of lymphatic endothelial cells and involved in hyaluronan uptake. Together these markers identify lymphatic ECs and distinguish them from capillary, arterial, and venous endothelial subtypes.
Rationale DOI: 10.1038/s42255-025-01296-9

Ontology Term: endothelial cell of lymphatic vesselCL:0002138
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: LEC, lymphatic endothelial cell
Category Class of which the cell type is a subclass.: endothelial cellCL:0000115
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PECAM1, MECOM, CDH5, ENPEP, PROX1, LYVE1
Canonical Marker Genes: PECAM1, MECOM, CDH5, ENPEP, PROX1, LYVE1
Rationale: PECAM1 (CD31) and CDH5 (VE-cadherin) are pan-endothelial markers confirming endothelial identity, while MECOM and ENPEP further support this. PROX1 is a transcription factor required for lymphatic endothelial cell specification and maintenance, and LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1) is expressed on the surface of lymphatic endothelial cells and involved in hyaluronan uptake. Together these markers identify lymphatic ECs and distinguish them from capillary, arterial, and venous endothelial subtypes.
Rationale DOI: 10.1038/s42255-025-01296-9