Human Adipose Tissue Atlas v1.0 — Abdominal Visceral WAT

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Cell Metadata

DPP4⁺ ASPCs

Ontology Term: fibro/adipogenic progenitor cellCL:0009099
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: mesenchymal stem cell of adipose tissue, preadipocyte
Category Class of which the cell type is a subclass.: progenitor cellCL:0011026
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PDGFRA, DCN, DPP4, CD55, PI16
Canonical Marker Genes: PDGFRA, DCN, DPP4, CD55, PI16
Rationale: PDGFRA and DCN (decorin) are general ASPC/stromal markers broadly expressed across adipose stromal and progenitor cell populations. DPP4 (dipeptidyl peptidase 4), CD55 (decay accelerating factor), and PI16 (peptidase inhibitor 16) show enriched expression in this specific subpopulation, together distinguishing DPP4⁺ ASPCs from other ASPC subtypes. Together these markers identify a distinct ASPC subpopulation within the broader stromal compartment.
Rationale DOI: 10.1038/s42255-025-01296-9

Ontology Term: fibro/adipogenic progenitor cellCL:0009099
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: mesenchymal stem cell of adipose tissue, preadipocyte
Category Class of which the cell type is a subclass.: progenitor cellCL:0011026
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PDGFRA, DCN, DPP4, CD55, PI16
Canonical Marker Genes: PDGFRA, DCN, DPP4, CD55, PI16
Rationale: PDGFRA and DCN (decorin) are general ASPC/stromal markers broadly expressed across adipose stromal and progenitor cell populations. DPP4 (dipeptidyl peptidase 4), CD55 (decay accelerating factor), and PI16 (peptidase inhibitor 16) show enriched expression in this specific subpopulation, together distinguishing DPP4⁺ ASPCs from other ASPC subtypes. Together these markers identify a distinct ASPC subpopulation within the broader stromal compartment.
Rationale DOI: 10.1038/s42255-025-01296-9