Human Adipose Tissue Atlas v1.0 — Lymphoid cells

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Cell Metadata

Plasma cells

Ontology Term: plasma cellCL:0000786
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: plasma B-cell, plasma B cell, effector B cell, plasmocyte, plasmacyte, effector B-cell
Category Class of which the cell type is a subclass.: B cellCL:0000236
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: JCHAIN, MZB1
Canonical Marker Genes: JCHAIN, MZB1
Rationale: JCHAIN (joining chain) is a component of polymeric immunoglobulins and is highly expressed in antibody-secreting cells. MZB1 (marginal zone B and B1 cell-specific protein) is an endoplasmic reticulum protein involved in immunoglobulin secretion, enriched in plasmablasts and plasma cells. Together these markers identify antibody-secreting plasma cells and distinguish them from naive and memory B cell populations.
Rationale DOI: 10.1038/s42255-025-01296-9 10.57785/e9e1-wh09

Ontology Term: plasma cellCL:0000786
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: plasma B-cell, plasma B cell, effector B cell, plasmocyte, plasmacyte, effector B-cell
Category Class of which the cell type is a subclass.: B cellCL:0000236
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: JCHAIN, MZB1
Canonical Marker Genes: JCHAIN, MZB1
Rationale: JCHAIN (joining chain) is a component of polymeric immunoglobulins and is highly expressed in antibody-secreting cells. MZB1 (marginal zone B and B1 cell-specific protein) is an endoplasmic reticulum protein involved in immunoglobulin secretion, enriched in plasmablasts and plasma cells. Together these markers identify antibody-secreting plasma cells and distinguish them from naive and memory B cell populations.
Rationale DOI: 10.1038/s42255-025-01296-9 10.57785/e9e1-wh09