Human Adipose Tissue Atlas v1.0 — Lymphoid cells

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Cell Metadata

Cytotoxic CD8⁺ T cells

Ontology Term: CD8-positive, alpha-beta cytotoxic T cellCL:0000794
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: cytotoxic T cell, killer T lymphocyte, killer T-cell, CD8-positive, alpha-beta cytotoxic T-cell, killer T-lymphocyte, cytotoxic T-lymphocyte, cytotoxic T-cell, alpha-beta cytotoxic T lymphocyte, cytotoxic T lymphocyte, killer T cell, alpha-beta cytotoxic T-lymphocyte
Category Class of which the cell type is a subclass.: T cellCL:0000084
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CD8A, PRF1, GZMB, CX3CR1
Canonical Marker Genes: CD8A, PRF1, GZMB, CX3CR1
Rationale: CD8A confirms CD8⁺ T cell lineage identity. PRF1 (perforin-1) and GZMB (granzyme B) are cytotoxic effector molecules stored in cytotoxic granules and are characteristic of cells with cytotoxic activity. CX3CR1 (fractalkine receptor) shows enriched expression in terminally differentiated cytotoxic T cells and is associated with effector memory and tissue-patrolling states. Together these markers identify cytotoxic CD8⁺ T cells and distinguish them from naive and memory CD8⁺ T cell populations.
Rationale DOI: 10.57785/e9e1-wh09 10.1038/s42255-025-01296-9

Ontology Term: CD8-positive, alpha-beta cytotoxic T cellCL:0000794
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: cytotoxic T cell, killer T lymphocyte, killer T-cell, CD8-positive, alpha-beta cytotoxic T-cell, killer T-lymphocyte, cytotoxic T-lymphocyte, cytotoxic T-cell, alpha-beta cytotoxic T lymphocyte, cytotoxic T lymphocyte, killer T cell, alpha-beta cytotoxic T-lymphocyte
Category Class of which the cell type is a subclass.: T cellCL:0000084
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CD8A, PRF1, GZMB, CX3CR1
Canonical Marker Genes: CD8A, PRF1, GZMB, CX3CR1
Rationale: CD8A confirms CD8⁺ T cell lineage identity. PRF1 (perforin-1) and GZMB (granzyme B) are cytotoxic effector molecules stored in cytotoxic granules and are characteristic of cells with cytotoxic activity. CX3CR1 (fractalkine receptor) shows enriched expression in terminally differentiated cytotoxic T cells and is associated with effector memory and tissue-patrolling states. Together these markers identify cytotoxic CD8⁺ T cells and distinguish them from naive and memory CD8⁺ T cell populations.
Rationale DOI: 10.57785/e9e1-wh09 10.1038/s42255-025-01296-9