Human Adipose Tissue Atlas v1.0 — Lymphoid cells

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Cell Metadata

Memory CD4⁺ T cells

Ontology Term: CD4-positive, alpha-beta memory T cellCL:0000897
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: CD4-positive, alpha-beta memory T lymphocyte, T4.Mem.Sp, alpha-beta memory T-lymphocyte, alpha-beta memory T-cell
Category Class of which the cell type is a subclass.: T cellCL:0000084
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CD4, LEF1, ITGB1
Canonical Marker Genes: CD4, LEF1, ITGB1
Rationale: CD4 is a surface co-receptor confirming CD4⁺ T cell lineage identity. LEF1 (lymphoid enhancer binding factor 1) is a transcription factor associated with memory T cell states. ITGB1 (integrin beta-1) is involved in T cell adhesion and tissue retention, with enriched expression in memory T cell populations. Together these markers identify memory CD4⁺ T cells and distinguish them from naive and effector CD4⁺ T cell populations.
Rationale DOI: 10.57785/e9e1-wh09

Ontology Term: CD4-positive, alpha-beta memory T cellCL:0000897
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: CD4-positive, alpha-beta memory T lymphocyte, T4.Mem.Sp, alpha-beta memory T-lymphocyte, alpha-beta memory T-cell
Category Class of which the cell type is a subclass.: T cellCL:0000084
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CD4, LEF1, ITGB1
Canonical Marker Genes: CD4, LEF1, ITGB1
Rationale: CD4 is a surface co-receptor confirming CD4⁺ T cell lineage identity. LEF1 (lymphoid enhancer binding factor 1) is a transcription factor associated with memory T cell states. ITGB1 (integrin beta-1) is involved in T cell adhesion and tissue retention, with enriched expression in memory T cell populations. Together these markers identify memory CD4⁺ T cells and distinguish them from naive and effector CD4⁺ T cell populations.
Rationale DOI: 10.57785/e9e1-wh09