Human Adipose Tissue Atlas v1.0 — Lymphoid cells

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Cell Metadata

Mucosal-associated invariant T cells

Ontology Term: mucosal-associated invariant T cellCL:0000940
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: MAIT, mucosal invariant T-cell, mucosal-associated invariant T-lymphocyte, mucosal invariant T cell
Category Class of which the cell type is a subclass.: T cellCL:0000084
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CD3D, CD3E, CD8A, KLRB1, SLC4A10
Canonical Marker Genes: CD3D, CD3E, CD8A, KLRB1, SLC4A10
Rationale: CD3D and CD3E are components of the T cell receptor signaling complex, confirming T cell lineage identity. CD8A confirms a cytotoxic T cell co-receptor expression profile. KLRB1 (CD161) and SLC4A10 are enriched in mucosal-associated invariant T cells (MAITs) specifically, with SLC4A10 being a well-characterized MAIT cell marker involved in bicarbonate transport. Together these markers identify MAIT cells and distinguish them from conventional CD8⁺ and CD4⁺ T cell populations.
Rationale DOI: 10.1038/s42255-025-01296-9

Ontology Term: mucosal-associated invariant T cellCL:0000940
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: MAIT, mucosal invariant T-cell, mucosal-associated invariant T-lymphocyte, mucosal invariant T cell
Category Class of which the cell type is a subclass.: T cellCL:0000084
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CD3D, CD3E, CD8A, KLRB1, SLC4A10
Canonical Marker Genes: CD3D, CD3E, CD8A, KLRB1, SLC4A10
Rationale: CD3D and CD3E are components of the T cell receptor signaling complex, confirming T cell lineage identity. CD8A confirms a cytotoxic T cell co-receptor expression profile. KLRB1 (CD161) and SLC4A10 are enriched in mucosal-associated invariant T cells (MAITs) specifically, with SLC4A10 being a well-characterized MAIT cell marker involved in bicarbonate transport. Together these markers identify MAIT cells and distinguish them from conventional CD8⁺ and CD4⁺ T cell populations.
Rationale DOI: 10.1038/s42255-025-01296-9