Human Adipose Tissue Atlas v1.0 — Lymphoid cells

Main

Cell Metadata

Treg cells

Ontology Term: regulatory T cellCL:0000815
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: suppressor T cell, regulatory T lymphocyte, regulatory T-cell, suppressor T-cell, Treg
Category Class of which the cell type is a subclass.: T cellCL:0000084
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CD3D, CD3E, FOXP3, TIGIT, CTLA4
Canonical Marker Genes: CD3D, CD3E, FOXP3, TIGIT, CTLA4
Rationale: CD3D and CD3E are components of the T cell receptor signaling complex, confirming T cell lineage identity. FOXP3 is a transcription factor required for regulatory T cell specification and function, and is the defining marker of this population. TIGIT and CTLA4 are inhibitory receptors enriched in regulatory T cells, reflecting their immunosuppressive function. Together these markers reliably identify regulatory T cells (Tregs) and distinguish them from conventional CD4⁺ and CD8⁺ T cell populations.
Rationale DOI: 10.1038/s42255-025-01296-9

Ontology Term: regulatory T cellCL:0000815
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: suppressor T cell, regulatory T lymphocyte, regulatory T-cell, suppressor T-cell, Treg
Category Class of which the cell type is a subclass.: T cellCL:0000084
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CD3D, CD3E, FOXP3, TIGIT, CTLA4
Canonical Marker Genes: CD3D, CD3E, FOXP3, TIGIT, CTLA4
Rationale: CD3D and CD3E are components of the T cell receptor signaling complex, confirming T cell lineage identity. FOXP3 is a transcription factor required for regulatory T cell specification and function, and is the defining marker of this population. TIGIT and CTLA4 are inhibitory receptors enriched in regulatory T cells, reflecting their immunosuppressive function. Together these markers reliably identify regulatory T cells (Tregs) and distinguish them from conventional CD4⁺ and CD8⁺ T cell populations.
Rationale DOI: 10.1038/s42255-025-01296-9