Human Adipose Tissue Atlas v1.0 — Lymphoid cells

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Cell Metadata

CD56⁺CD16⁺ NK cells

Ontology Term: CD16-positive, CD56-dim natural killer cell, humanCL:0000939
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: CD16-positive, CD56-dim NK cell, cytotoxic CD56-dim NK cell, CD16+CD56+ NK cell, CD56-low natural killer cell, CD56-positive NK cell, CD56-low NK cell, CD56-positive natural killer cell, cytotoxic CD56-dim natural killer cell
Category Class of which the cell type is a subclass.: natural killer cellCL:0000623
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: NCR1, NCAM1, GNLY, KLRD1, PRF1, FCGR3A, FGFBP2, KLRF1
Canonical Marker Genes: NCR1, NCAM1, GNLY, KLRD1, PRF1, FCGR3A, FGFBP2, KLRF1
Rationale: NCR1 (NKp46) and NCAM1 (CD56) confirm NK cell lineage identity. GNLY (granulysin), PRF1 (perforin-1), and KLRD1 (CD94) reflect cytotoxic capacity broadly shared across NK cell populations. FCGR3A (CD16) defines the CD16⁺ subset and is involved in antibody-dependent cellular cytotoxicity. FGFBP2 and KLRF1 show enriched expression in this mature cytotoxic NK cell subset in adipose tissue single-cell datasets. Together these markers identify CD56⁺CD16⁺ NK cells and distinguish them from CD16⁻ NK cell populations.
Rationale DOI: 10.57785/e9e1-wh09 10.1038/s42255-025-01296-9

Ontology Term: CD16-positive, CD56-dim natural killer cell, humanCL:0000939
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: CD16-positive, CD56-dim NK cell, cytotoxic CD56-dim NK cell, CD16+CD56+ NK cell, CD56-low natural killer cell, CD56-positive NK cell, CD56-low NK cell, CD56-positive natural killer cell, cytotoxic CD56-dim natural killer cell
Category Class of which the cell type is a subclass.: natural killer cellCL:0000623
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: NCR1, NCAM1, GNLY, KLRD1, PRF1, FCGR3A, FGFBP2, KLRF1
Canonical Marker Genes: NCR1, NCAM1, GNLY, KLRD1, PRF1, FCGR3A, FGFBP2, KLRF1
Rationale: NCR1 (NKp46) and NCAM1 (CD56) confirm NK cell lineage identity. GNLY (granulysin), PRF1 (perforin-1), and KLRD1 (CD94) reflect cytotoxic capacity broadly shared across NK cell populations. FCGR3A (CD16) defines the CD16⁺ subset and is involved in antibody-dependent cellular cytotoxicity. FGFBP2 and KLRF1 show enriched expression in this mature cytotoxic NK cell subset in adipose tissue single-cell datasets. Together these markers identify CD56⁺CD16⁺ NK cells and distinguish them from CD16⁻ NK cell populations.
Rationale DOI: 10.57785/e9e1-wh09 10.1038/s42255-025-01296-9