Human Adipose Tissue Atlas v1.0 — Lymphoid cells

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Cell Metadata

CD56⁺CD16⁻ NK cells

Ontology Term: CD16-negative, CD56-bright natural killer cell, humanCL:0000938
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: CD16-CD56bright NK cell, CD16-negative, CD56-bright NK cell, CD56-bright cytokine secreting natural killer cell, CD56-bright cytokine secreting NK cell
Category Class of which the cell type is a subclass.: natural killer cellCL:0000623
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: NCR1, NCAM1
Canonical Marker Genes: NCR1, NCAM1
Rationale: NCR1 (NKp46) and NCAM1 (CD56) confirm NK cell lineage identity. This population is defined by the absence of FCGR3A (CD16) expression, distinguishing it from the more cytotoxic CD56⁺CD16⁺ NK cell subset. Together these markers identify CD56⁺CD16⁻ NK cells within the broader NK cell compartment.
Rationale DOI: 10.57785/e9e1-wh09 10.1038/s42255-025-01296-9

Ontology Term: CD16-negative, CD56-bright natural killer cell, humanCL:0000938
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: CD16-CD56bright NK cell, CD16-negative, CD56-bright NK cell, CD56-bright cytokine secreting natural killer cell, CD56-bright cytokine secreting NK cell
Category Class of which the cell type is a subclass.: natural killer cellCL:0000623
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: NCR1, NCAM1
Canonical Marker Genes: NCR1, NCAM1
Rationale: NCR1 (NKp46) and NCAM1 (CD56) confirm NK cell lineage identity. This population is defined by the absence of FCGR3A (CD16) expression, distinguishing it from the more cytotoxic CD56⁺CD16⁺ NK cell subset. Together these markers identify CD56⁺CD16⁻ NK cells within the broader NK cell compartment.
Rationale DOI: 10.57785/e9e1-wh09 10.1038/s42255-025-01296-9