Human Adipose Tissue Atlas v1.0 — Myeloid cells

Main

Cell Metadata

cDC2B

Ontology Term: dendritic cellCL:0000451
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: interdigitating cell, veiled cell
Category Class of which the cell type is a subclass.: dendritic cellCL:0000451
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FLT3, FCER1A, CD1C, CLEC10A, IRF4
Canonical Marker Genes: FLT3, FCER1A, CD1C, CLEC10A, IRF4
Rationale: FLT3 is a general dendritic cell marker expressed across DC progenitors and mature DC subsets. FCER1A (high-affinity IgE receptor), CD1C, CLEC10A, and IRF4 show enriched expression in cDC2s specifically, with IRF4 being a transcription factor involved in cDC2 differentiation and function. Together these markers identify cDC2B and distinguish them from cDC1 and other dendritic cell subsets.
Rationale DOI: 10.1038/s42255-025-01296-9

Ontology Term: dendritic cellCL:0000451
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: interdigitating cell, veiled cell
Category Class of which the cell type is a subclass.: dendritic cellCL:0000451
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FLT3, FCER1A, CD1C, CLEC10A, IRF4
Canonical Marker Genes: FLT3, FCER1A, CD1C, CLEC10A, IRF4
Rationale: FLT3 is a general dendritic cell marker expressed across DC progenitors and mature DC subsets. FCER1A (high-affinity IgE receptor), CD1C, CLEC10A, and IRF4 show enriched expression in cDC2s specifically, with IRF4 being a transcription factor involved in cDC2 differentiation and function. Together these markers identify cDC2B and distinguish them from cDC1 and other dendritic cell subsets.
Rationale DOI: 10.1038/s42255-025-01296-9