Human Adipose Tissue Atlas v1.0 — Myeloid cells

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Cell Metadata

CD14⁺CD16⁺ Monocytes

Ontology Term: CD14-positive, CD16-positive monocyteCL:0002397
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: CD16+ monocyte
Category Class of which the cell type is a subclass.: monocyteCL:0000576
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FCN1, FCGR3A, HES4, LST1, DGKG
Canonical Marker Genes: FCN1, FCGR3A, HES4, LST1, DGKG
Rationale: FCN1 (ficolin-1) is a pattern recognition molecule with enriched expression in monocytes broadly. FCGR3A (CD16), HES4, LST1, and DGKG show enriched expression in CD14⁺CD16⁺ non-classical monocytes specifically, with FCGR3A being the defining surface marker of this subset. Together these markers identify the non-classical monocyte subset and distinguish them from classical monocyte populations.
Rationale DOI: 10.1038/s42255-025-01296-9

Ontology Term: CD14-positive, CD16-positive monocyteCL:0002397
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: CD16+ monocyte
Category Class of which the cell type is a subclass.: monocyteCL:0000576
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FCN1, FCGR3A, HES4, LST1, DGKG
Canonical Marker Genes: FCN1, FCGR3A, HES4, LST1, DGKG
Rationale: FCN1 (ficolin-1) is a pattern recognition molecule with enriched expression in monocytes broadly. FCGR3A (CD16), HES4, LST1, and DGKG show enriched expression in CD14⁺CD16⁺ non-classical monocytes specifically, with FCGR3A being the defining surface marker of this subset. Together these markers identify the non-classical monocyte subset and distinguish them from classical monocyte populations.
Rationale DOI: 10.1038/s42255-025-01296-9