Human Adipose Tissue Atlas v1.0 — Myeloid cells

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Cell Metadata

cDC1

Ontology Term: conventional dendritic cellCL:0000990
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: cDC, DC1, interdigitating cell, dendritic reticular cell, type 1 DC, veiled cell
Category Class of which the cell type is a subclass.: dendritic cellCL:0000451
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FLT3, XCR1, CLEC9A, CADM1, DPP4
Canonical Marker Genes: FLT3, XCR1, CLEC9A, CADM1, DPP4
Rationale: FLT3 is a general dendritic cell marker expressed across DC progenitors and mature DC subsets. XCR1, CLEC9A (DNGR-1), CADM1, and DPP4 show enriched expression in cDC1s specifically, with XCR1 and CLEC9A being well-characterized surface markers of this subset involved in cross-presentation of antigens. Together these markers identify cDC1s and distinguish them from cDC2 and other dendritic cell subsets.
Rationale DOI: 10.1038/s42255-025-01296-9

Ontology Term: conventional dendritic cellCL:0000990
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: cDC, DC1, interdigitating cell, dendritic reticular cell, type 1 DC, veiled cell
Category Class of which the cell type is a subclass.: dendritic cellCL:0000451
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FLT3, XCR1, CLEC9A, CADM1, DPP4
Canonical Marker Genes: FLT3, XCR1, CLEC9A, CADM1, DPP4
Rationale: FLT3 is a general dendritic cell marker expressed across DC progenitors and mature DC subsets. XCR1, CLEC9A (DNGR-1), CADM1, and DPP4 show enriched expression in cDC1s specifically, with XCR1 and CLEC9A being well-characterized surface markers of this subset involved in cross-presentation of antigens. Together these markers identify cDC1s and distinguish them from cDC2 and other dendritic cell subsets.
Rationale DOI: 10.1038/s42255-025-01296-9