Human Adipose Tissue Atlas v1.0 — Myeloid cells

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Cell Metadata

CD14⁺CD16⁻ Monocytes

Ontology Term: CD14-positive, CD16-negative classical monocyteCL:0002057
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: CD16-negative monocyte, CD16- monocyte
Category Class of which the cell type is a subclass.: monocyteCL:0000576
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FCN1, FCER1A, TXNIP, FCAR
Canonical Marker Genes: FCN1, FCER1A, TXNIP, FCAR
Rationale: FCN1 (ficolin-1) is a pattern recognition molecule with enriched expression in classical monocytes. FCER1A, TXNIP (thioredoxin interacting protein), and FCAR (Fc alpha receptor, CD89) show enriched expression in CD14⁺CD16⁻ classical monocytes specifically. Together these markers identify the classical monocyte subset and distinguish them from non-classical and intermediate monocyte populations.
Rationale DOI: 10.1038/s42255-025-01296-9

Ontology Term: CD14-positive, CD16-negative classical monocyteCL:0002057
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: CD16-negative monocyte, CD16- monocyte
Category Class of which the cell type is a subclass.: monocyteCL:0000576
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FCN1, FCER1A, TXNIP, FCAR
Canonical Marker Genes: FCN1, FCER1A, TXNIP, FCAR
Rationale: FCN1 (ficolin-1) is a pattern recognition molecule with enriched expression in classical monocytes. FCER1A, TXNIP (thioredoxin interacting protein), and FCAR (Fc alpha receptor, CD89) show enriched expression in CD14⁺CD16⁻ classical monocytes specifically. Together these markers identify the classical monocyte subset and distinguish them from non-classical and intermediate monocyte populations.
Rationale DOI: 10.1038/s42255-025-01296-9