Human Adipose Tissue Atlas v1.0 — Myeloid cells

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Cell Metadata

Activated DCs

Ontology Term: dendritic cellCL:0000451
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: interdigitating cell, veiled cell
Category Class of which the cell type is a subclass.: dendritic cellCL:0000451
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FLT3, CCR7, FSCN1, CCL22, LAMP3
Canonical Marker Genes: FLT3, CCR7, FSCN1, CCL22, LAMP3
Rationale: FLT3 is a general dendritic cell marker expressed across DC progenitors and mature DC subsets. CCR7, FSCN1, CCL22, and LAMP3 show enriched expression in activated/migratory DCs, reflecting an activation and maturation state rather than a fixed DC subset identity. Together these markers identify a transcriptionally distinct activated DC population and distinguish them from resident cDC1 and cDC2 subsets.
Rationale DOI: 10.1038/s42255-025-01296-9

Ontology Term: dendritic cellCL:0000451
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: interdigitating cell, veiled cell
Category Class of which the cell type is a subclass.: dendritic cellCL:0000451
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FLT3, CCR7, FSCN1, CCL22, LAMP3
Canonical Marker Genes: FLT3, CCR7, FSCN1, CCL22, LAMP3
Rationale: FLT3 is a general dendritic cell marker expressed across DC progenitors and mature DC subsets. CCR7, FSCN1, CCL22, and LAMP3 show enriched expression in activated/migratory DCs, reflecting an activation and maturation state rather than a fixed DC subset identity. Together these markers identify a transcriptionally distinct activated DC population and distinguish them from resident cDC1 and cDC2 subsets.
Rationale DOI: 10.1038/s42255-025-01296-9